High-dose vitamin E supplementation normalizes retinal blood flow and creatinine clearance in patients with type I diabetes. Robertson J McD, Donner AP, Trevithick JR. A possible role for vitamins C and E in cataract prevention. 58. 234. Norkus EP, Bryce GF, Bhagavan HN. 2002;288:715–21. 287. Vitamin E is known for its anti-aging and anti-inflammatory properties, but its effects extend beyond skincare! Bates B. Vitamin E gets an ‘F’ for wound healing, scarring. A prospective study of vitamin supplement intake and cataract extraction among U.S. women. Polidori MC, Mecocci P, Stahl W, et al. Proc Soc Exp Biol Med 2000;223:170–4. 176. This article reviews vitamin E toxicity, including its symptoms and side effects, as well as how to treat and prevent it. Vitamin A, vitamin E or beta-carotene status and hepatitis B-related hepatocellular carcinoma. J Am Coll Nutr 1996;15:458–61. Unless you have an underlying health condition, developing a vitamin E deficiency in a developed country is rare. However, in high doses it may cause nausea, bleeding, stomach pain, flatulence, diarrhea, headaches and blurred vision. J Infect Dis 2000;182:S93–S96 [review]. Thiessen DD, Ondrusek G, Coleman RV. Garmyn M, Ribaya-Mercado JD, Russel RM, et al. Daily vitamin E supplements improve metabolic control but not insulin secretion in elderly type II diabetic patients. Along with its needed effects, vitamin e may cause some unwanted effects. Vitamin E and benign breast “disease”: a double-blind, randomized clinical trial. J Nutr 2001;131:395S–7S. Topical melatonin in combination with vitamins E and C protects skin from ultraviolet-induced erythema: a human study in vivo. Vitamin C deficiency in patients with sickle cell anemia. N Engl J Med 1981;305:1365–71. The tolerable upper limit dose of vitamin E for adults is 1,000 mg. High doses above 1,000 mg have been associated with the following side effects: dizziness fatigue headaches weakness blurred vision abdominal pain diarrhea nausea Malilila N, Virtamo J, Virtanen M, et al. Stebbing JB et al. Cancer Epidemiol Biomarkers Prev 1997;6:769–74. Natta CL, Machlin LJ, Brin M. A decrease in irreversibly sickled erythrocytes in sickle cell anemia patients given vitamin E. Am J Clin Nutr 1980;33:968–71. LIVESTRONG is a registered trademark of the LIVESTRONG Foundation. Joe King began writing fitness and nutrition articles in 2001 for the "Journal of Hyperplasia Research" and Champion Nutrition. 228. Food Addit Contam. 145. Mathews-Roth MM, Pathak MA, Parrish J, et al. Although vitamin E is a necessary nutrient, it’s possible to overdose on it — especially when taking supplements. Knekt P, Heliovaara M, Rissanen A, et al. Regression of oral leukoplakia with alpha-tocopherol: a community clinical oncology program chemoprevention study. Pack AR. Overdose is unlikely to happen as a result of eating vitamin-E-rich foods alone (1). Serum antioxidant vitamins and risk of cataract. 339. Dietary antioxidants and Parkinson disease. J Am Coll Nutr 1989;8:636–43 [review]. Roob JM, Khoschsorur G, Tiran A, et al. Ceriello A, Giugliano D, Quatraro A, et al. De Hoff JB, Ozazewski J. Alpha tocopherol to treat diabetic retinopathy. Med Hypotheses 1984;13:77–98. Potential clinical applications for high-dose nutritional antioxidants. 47. The Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group. Salonen JT, Nyyssönen K, Salonen R, et al. Eberlein-Konig B, Placzek M, Przybilla B. Daily vitamin E supplements improve metabolic control but not insulin secretion in elderly type II diabetic patients. 168. Beck MA. Int J Sports Med 2002;23:10–15. Palmieri B, Gozzi G, Palmieri G. Vitamin E added silicone gel sheets for treatment of hypertrophic scars and keloids. Dermatology 1997;195:248–52. Treatment for minor vitamin E toxicity includes discontinuing the use of your vitamin E supplement, but more serious complications may require medical intervention. 96. Reactive hypoglycemia and magnesium. 281. 172. 136. Vitamin E supplementation attenuates leakage of enzymes following 6 successive days of running training. Rapola RM, Virtamo J, Haukka JK, et al. West S, Vitale S, Hallfrisch J, et al. 252. Lethem R, Orrell M. Antioxidants and dementia. Fahn S. A pilot trial of high-dose alpha-tocopherol and ascorbate in early Parkinson’s disease. Diabetes Care 1993;16:1433–7. 371. 337. J Infect Dis 1997;176:273–6. Jacques PF, Chylack LT Jr. Epidemiologic evidence of a role for the antioxidant vitamins and carotenoids in cataract prevention. Wright JW. Lohrr JB, Cadet JL, Lohr MA. Vitamin E and climacteric syndrome: failure of effective control as measured by menopausal index. As always, please consult with a licensed doctor or physician before starting any diet, exercise or supplement program, before taking any vitamin or medication, or if you have or suspect you might have a problem. Serum vitamin E and the sickling status in children with sickle cell anemia. 226. Fink M, Fink J. Goldberg J, Flowerdew G, Smith E, et al. Maes M, De Vos N, Pioli R, et al. Lancet 1996;347:781–6. Lee J, Jiang S, Levine N, Watson RR. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Ljunghall K, Juhlin L, Edqvist LE, Plantin LO. Effect of micronutrient supplementation on infection in institutionalized elderly subjects: a controlled trial. 152. Slowing down the processes that damage cells. Pharmacologic doses of vitamin E improve insulin action in healthy subjects and non-insulin dependent diabetic patients. 368. You may report them to the FDA. Can J Ophthalmol 1982;17:61. Dent Survey 1976;52(7):50–1. was based used a combination of nutritional supplements, not just vitamin E. For
238. Deprenyl And Tocopherol Antioxidative Therapy Of Parkinsonism. 258. Tocopherol acetate has many potential nutrition and health applications, and it is commonly found in oral supplements as well as dermatological creams that are applied to your skin. Menkes MS, Comstock GW, Vuilleumier JP, et al. Potential clinical applications for high-dose nutritional antioxidants. A dose response study. Supplementation of patients with homozygous sickle cell disease with zinc, alpha-tocopherol, vitamin C, soybean oil, and fish oil. Townsend Letter for Doctors & Patients 1999;July:100–5 [review]. Am J Epidemiol 1999;149:801–9. Pappert EJ, Tangney CC, Goetz CG, et al. Diabetes Care 1991;14:68–72. 420. Sajjad SHA. Muskiet FA, Muskiet FD, Meiborg G, Schermer JG. 250. 13. 297. 313. A dose response study. This research has been criticized because many of the studies on which it
Reaven PD, Barnett J, Herold DA, Edelman S. Effect of vitamin E on susceptibility of low-density lipoprotein and low-density lipoprotein subfractions to oxidation and on protein glycation in NIDDM. 265. 131. Alpha-tocopherol, lipids and lipoproteins in knee-joint synovial fluid and serum from patients with inflammatory joint disease. Mezes M, Par A, Nemeth P, Javor T. Studies of the blood lipid peroxide status and vitamin E levels in patients with chronic active hepatitis and alcoholic liver disease. Reduced chronic hemolysis during high-dose vitamin E administration in Mediterranean-type glucose-6-phosphate dehydrogenase deficiency. The Daily Value (DV) for vitamin E is 15 mg per day. 359. What are the uses of Vitamin E Acetate / Xanthan Gum? For elderly individuals, the risks and benefits of taking this
In vivo effects of vitamin E on cataractogenesis in diabetic rats. Do not flush medications down the toilet or pour them into drainage unless instructed to do so. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. rates. 183. Wolf C, Steiner A, Honigsmann H, et al. Low plasma prealbumin and carotenoid levels in sickle cell disease patients. Mov Disord 1997;12:190–6. Jenkins M, Alexander W, MacMillan BG. [No authors listed]. 60. Arch Dermatol 1975;111:396. 149. Piesse JW. Vitamin E capsules spilling from a bottle, SCCNFP; The Use of Alpha-tocopherol Acetate in Cosmetic Products; Sept 2001, Linus Pauling Institute; Vitamin E; Jane Higdon; 2004, "International Journal of Toxicology"; Final Report on the Safety Assessment of Tocopherol, Tocopheryl Acetate, Tocopheryl Linoleate, Tocopheryl Linoleate/Oleate, Tocopheryl Nicotinate, Tocopheryl Succinate, Dioleyl Tocopheryl Methylsilanol, Potassium Ascorbyl Tocopheryl Phosphate, and Tocophersolan; Nov 2002, PARTNER & LICENSEE OF THE LIVESTRONG FOUNDATION. Ayres S, Mihan R. Leg cramps and “restless leg” syndrome responsive to vitamin E. Calif Med 1969;111:87–91.
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